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Results A total of 113 extended trials were included in the study. Main Outcomes and Measures Outcomes in the pairs of original and extended trials were categorized according to whether any benefits or harms from interventions were sustained, were lost, or emerged during long-term follow-up.

IS REALFLIGHT 7.5 FREE DEMO STILL AVALIABLE TRIAL

Determination of study eligibility and extraction of information about trial characteristics and outcomes, for both original and extended trial reports, were performed in duplicate.ĭata Extraction and Synthesis Assessment of study eligibility and data extraction were performed independently by 2 reviewers. Study Selection Various combinations of search terms were used, as there is no accepted terminology. Objective To perform a scoping review of randomized clinical trials extended by record linkage to characterize this literature and explore any additional insights into treatment effectiveness provided by long-term follow-up using record linkage.ĭata Sources A literature search in Embase, CINAHL, MEDLINE, and the Cochrane Register of Controlled Trials was performed for the period January 1, 1945, through November 25, 2016. Some important randomized trials have been extended well beyond their original follow-up period by linkage of individual participant information to routinely collected data held in administrative records and registries. Importance Follow-up of participants in randomized trials may be limited by logistic and financial factors. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.

Challenges in Clinical Electrocardiography.

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